Neural Circuit Structure
The central nervous system contains thousands of neurons, each of which ultimately achieves a specific functional fate. How are neurons recruited into specific neural circuits? Are there fundamental organizing principles that are shared across different networks? What are the consequences of these principles for behavior?
Circuit Development and Robustness
To support neural circuit function, each neuron needs to establish useful synaptic connections - with the sensory periphery, with other neurons, or with muscle effectors. What strategies do neurons use to guide synaptic connectivity? What role do these strategies play in shaping the landscape of neurodevelopmental disease? And how do these strategies constrain and facilitate brain evolution?
Development of Respiratory Motor Coordination
Respiratory behaviors involve multiple muscles acting in concert, and the details of this motor coordination change across the animal's lifetime. How are transitions during respiratory development reflected in the properties of neurons, populations, and networks across the brain?