RECENT RESEARCH
robust development of neural circuits
To support neural circuit function, each neuron needs to establish useful synaptic connections with other cells. What strategies do neurons use to guide synaptic connectivity? How do these strategies shape the landscape of neurodevelopmental disease? And how do these strategies constrain and facilitate brain evolution?
Ventral view of coordinated respiratory movements of the opercula and pectoral fins of a zebrafish larva at 5 days post-fertilization.
EARLY DEVELOPMENT OF RESPIRATORY MOTOR CIRCUITS
During early development, larval breathing behaviors change, as muscles and respiratory networks mature. Which respiratory circuit components arise first? Do synaptic contacts with motor neurons re-configure over time?
DENDRITE TOPOGRAPHY & SYNAPTIC TARGETING
Neurons extend membrane processes called dendrites, specialized for receiving synaptic inputs. Does dendrite topography predict functional topography? Does dendrite position guide synaptic targeting?
ONGOING RESEARCH
Image of the brain of a transgenic larval zebrafish, expressing a calcium indicator (green) under a pan-neuronal promoter and a membrane-targeted fluorescent protein (magenta) under a promoter specific to efferent neurons.
brain-wide respiratory networks
Breathing behaviors are critical for survival, and are generated by neurons in the hindbrain and spinal cord. Where are respiratory circuit components located? Which of these synapse directly onto facial motor neurons?